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Karyotyping

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What is Karyotyping?

Karyotyping is the cornerstone of cytogenetic analysis - a powerful technique that examines the complete set of chromosomes in a cell. This gold-standard method creates a detailed chromosomal "portrait," revealing the number, size, shape, and banding pattern of all 23 chromosome pairs.

By providing a panoramic view of the entire genome at the chromosomal level, karyotyping remains an essential diagnostic tool for detecting a wide spectrum of genetic abnormalities beyond what targeted tests can identify.

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Karyotyping recommended

Recommendation

When is Karyotyping Recommended?

  • Comprehensive Prenatal Testing: For thorough chromosomal analysis during pregnancy.
  • Recurrent Pregnancy Loss: To identify chromosomal causes of miscarriages.
  • Suspected Genetic Syndromes: When clinical features suggest chromosomal abnormalities.
  • Developmental Delays: In children with unexplained developmental issues.
  • Disorders of Sexual Development: For evaluation of ambiguous genitalia or atypical sexual development.
  • Infertility Investigation: To identify chromosomal factors affecting fertility.
  • Family History: When chromosomal abnormalities run in families.

Karyotyping provides a comprehensive view that can identify not only aneuploidies (abnormal chromosome numbers) but also structural changes like deletions, duplications, translocations and inversions that targeted molecular tests might miss.

Our Excellence

Our Karyotyping Excellence

At Suraksha Genomics, our conventional karyotyping service represents the pinnacle of cytogenetic precision:

Key Features

  • Complete Chromosomal Analysis : Examines all 23 pairs of chromosomes, not just specific targets.
  • Structural Abnormality Detection : Identifies translocations, inversions, deletions, and duplications.
  • Mosaicism Identification : Detects mixed cell populations with different chromosomal compositions.
  • Photographic Documentation : Provides complete karyogram images for physician review and medical records.

Sample Types We Analyze

  • Amniotic Fluid : From second-trimester amniocentesis procedures.
  • Chorionic Villus Sampling (CVS) : From first-trimester placental tissue sampling.
  • Peripheral Blood : For postnatal or adult chromosomal analysis.

Testing Process

The Karyotyping Process

Sample Collection

Sample Collection

A specimen is obtained by your healthcare provider through standard procedures.

Sample Collection

Cell Culture

Cells are cultivated in our specialized laboratory environment to promote division.

Sample Collection

Metaphase Arrest

Cell division is synchronized and halted at metaphase when chromosomes are most visible.

Sample Collection

Slide Preparation

Chromosomes are fixed, spread, and stained to reveal characteristic banding patterns.

Sample Collection

Microscopic Analysis

Skilled cytogeneticists examine multiple cell spreads under high-power microscopy.

Sample Collection

Digital Karyotyping

Chromosomes are digitally photographed, arranged and analyzed using specialized software.

Sample Collection

Expert Interpretation

Comprehensive analysis by our board-certified cytogeneticists.

Sample Collection

Detailed Reporting

Results delivered with clear clinical interpretation and karyogram images.

Sample Collection

Genetic Counseling

Expert consultation to explain findings and implications.

Why Suraksha Genomics?

Why Choose Suraksha Genomics for Karyotyping?

  • Optimized Culture Techniques : Advanced protocols to maximize culture success rates and minimize turnaround time.
  • Expert Cytogeneticist Team : Analysis performed by specialists with decades of combined experience.
  • High-Resolution Analysis : Superior chromosome banding quality for enhanced diagnostic accuracy.
  • Comprehensive Quality Controls : Rigorous internal and external quality assurance measures.
  • Integrated Genetic Services : Seamless coordination with molecular tests when additional information is needed.
  • Trusted Clinical Resource : Preferred cytogenetics partner for leading specialists across Eastern India.

your Result

Understanding Karyotype Results

Normal Karyotype

Displays the standard 46 chromosomes with expected structure and banding patterns.

Numerical Abnormalities

Identifies extra or missing chromosomes (e.g., trisomy 21 in Down syndrome, monosomy X in Turner syndrome).

Structural Rearrangements

Detects balanced and unbalanced translocations, inversions, deletions, and duplications.

Mosaicism

Reveals the presence of multiple cell lines with different chromosomal compositions.

Marker Chromosomes

Identifies extra chromosomal material of uncertain origin for further characterization.

FAQs

Frequently Asked Questions

What is Karyotyping?

Karyotyping is a genetic test that examines an individual's chromosomes – the structures that hold our DNA. It creates a "picture" of the chromosomes to count them and look for large changes in their size or structure, which can indicate genetic conditions.

What samples are used for Karyotyping at Suraksha Genomics?

We perform Karyotyping on:

  • Blood samples (for children or adults)
  • Amniotic Fluid (AF) (collected via amniocentesis during pregnancy)
  • Chorionic Villus Samples (CVS) (placental tissue collected during early pregnancy)
When is Karyotyping recommended?

Karyotyping may be recommended for individuals with suspected chromosomal syndromes (like Down syndrome), developmental delays, intellectual disabilities, infertility, recurrent pregnancy loss, or when prenatal screening suggests a chromosomal abnormality.

What can Karyotyping detect?

It can detect numerical abnormalities (e.g., an extra or missing chromosome) and large structural rearrangements (e.g., translocations, large deletions or duplications).

Have Questions?

We understand that genetic testing involves important decisions and potentially complex results. Our team of specialists is available to address your concerns, explain procedures, and provide the support you need throughout the testing process.

Contact our team today. Experience the confidence that comes from comprehensive chromosomal analysis by Eastern India's premier cytogenetics laboratory.

Consult our experts