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FISH for Aneuploidy

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What is FISH Testing for Aneuploidy?

Fluorescence In Situ Hybridization (FISH) is a sophisticated cytogenetic technique that allows direct visualization of specific chromosomes using fluorescent DNA probes. This powerful diagnostic method precisely identifies the presence, number and arrangement of chromosomes 13, 18, 21, X and Y - providing critical insights into chromosomal aneuploidies associated with genetic disorders.

FISH testing literally illuminates these chromosomes, making them visible under specialized microscopes to reveal their exact number and structure.

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what is FISH
Microarray recommended

Recommendation

When is FISH Testing Recommended?

  • Rapid Prenatal Diagnosis: When urgent results are needed for time-sensitive clinical decisions.
  • Confirmation Testing: To verify findings from other screening tests or inconclusive results.
  • High-Risk Pregnancies: For patients with increased likelihood of chromosomal abnormalities.
  • Abnormal Ultrasound Findings: When fetal imaging suggests possible chromosomal conditions
  • Ambiguous QF-PCR Results: To resolve unclear or borderline molecular testing outcomes.
  • Mosaicism Investigation: To detect and characterize chromosomal differences across cell populations.
  • Products of Conception Analysis: For determining chromosomal causes of pregnancy loss.

FISH provides exceptional clarity in detecting common aneuploidies while offering the significant advantage of speed - delivering answers within 24-48 hours when time is critical.

Our Excellence

Our FISH Testing Excellence

At Suraksha Genomics, our FISH analysis for aneuploidy detection represents the pinnacle of cytogenetic precision:

Key Features

  • Direct Visualization : Enables actual viewing of chromosomes rather than indirect detection methods.
  • Rapid Turnaround : Results available within 24-48 hours, comparable to QF-PCR speed.
  • High Specificity : Targeted probes for chromosomes 13, 18, 21, X, and Y minimize false positives.
  • Cell-by-Cell Analysis : Allows detection of chromosomal mosaicism missed by other techniques.
  • Uncultured Cell Capability : Can be performed on nondividing cells, eliminating culture failure risk.
  • Visual Documentation : Provides actual images of chromosomal findings for physician review.

Sample Types We Analyze

  • Amniotic Fluid : From second-trimester amniocentesis procedures.
  • Chorionic Villus Sampling (CVS) : From first-trimester placental tissue sampling.
  • Peripheral Blood : For postnatal confirmation or specific hematological conditions.

Testing Process

The FISH Testing Process

Sample Collection

Sample Collection

A small specimen is obtained by your healthcare provider through standard procedures.

Sample Collection

Cell Preparation

Our laboratory technicians isolate and fix cells on specialized slides.

Sample Collection

Probe Hybridization

DNA probes labeled with distinct fluorescent colors bind to specific chromosomes.

Sample Collection

Microscopic Analysis

Specialized fluorescence microscopy reveals the number of each target chromosome.

Sample Collection

Expert Interpretation

Analysis of multiple cells by our cytogenetics specialists.

Sample Collection

Comprehensive Reporting

Clear, clinically relevant results delivered within 24-48 hour.

Sample Collection

Genetic Counseling

Expert consultation to explain findings and implications.

Why Suraksha Genomics?

Why Choose Suraksha Genomics for FISH Testing?

  • Advanced Fluorescence Imaging : State-of-the-art microscopy systems for optimal signal detection and analysis.
  • Certified Cytogeneticists : Analysis performed by specialists with extensive training and experience in FISH techniques.
  • Multi-Probe Approach : Utilization of multiple probes per chromosome for enhanced accuracy.
  • Complementary Testing Options : Seamless integration with other genetic testing methods when appropriate.
  • Comprehensive Quality Controls : Rigorous internal and external quality assurance measures.
  • Trusted Clinical Resource : Preferred cytogenetics partner for leading maternal-fetal medicine specialists across Eastern India.

your Result

Understanding FISH Results

Normal Pattern

Shows two distinct fluorescent signals for each autosomal chromosome (13, 18, 21) and appropriate sex chromosome signals.

Trisomy

Reveals three fluorescent signals for a specific chromosome, indicating conditions like Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), or Patau syndrome (trisomy 13).

Monosomy

Displays a single signal for a chromosome, as seen in Turner syndrome (single X chromosome).

Sex Chromosome Variations

Identifies conditions like Klinefelter syndrome (XXY) and other sex chromosome compositions.

Mosaicism

Detects mixed cell populations with different chromosomal arrangements.

FAQs

Frequently Asked Questions

What is FISH for Aneuploidy?

Fluorescence In Situ Hybridization (FISH) is a rapid genetic test used to quickly detect common numerical chromosomal abnormalities. It uses fluorescent probes that bind to specific chromosomes.

When is FISH testing recommended?

FISH is often used when rapid results are needed for suspected common aneuploidies, especially in prenatal samples (Amniotic Fluid or CVS) or in newborns with features suggestive of these conditions.

Have Questions?

Our team understands the significance of genetic testing results and the impact they have on healthcare decisions. Our genetic counselors and laboratory specialists are available to answer your questions and provide supportive guidance throughout the testing process.

Contact our team today. Experience the clarity and confidence that comes from visual chromosome analysis by Eastern India's premier cytogenetics laboratory.

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