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QF-PCR Testing for Aneuploidy

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What is QF-PCR Testing?

Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) is an advanced molecular diagnostic test that provides rapid detection of common chromosomal aneuploidies - specifically chromosomes 13, 18, 21, X and Y.

This specialized test identifies whether the correct number of these critical chromosomes is present, detecting conditions such as Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), Patau syndrome (trisomy 13) and sex chromosome abnormalities with exceptional accuracy and speed.

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what is QF-PCR
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Recommendation

When is QF-PCR Testing Recommended?

  • Early Pregnancy Screening: For rapid results when time-sensitive decisions are needed.
  • High-Risk Pregnancies: When screening tests indicate elevated risk for chromosomal abnormalities.
  • Advanced Maternal Age: For women over 35 years with increased risk of chromosomal conditions.
  • Abnormal Ultrasound Findings: When structural abnormalities suggest potential chromosomal disorders.
  • Family History: When previous pregnancies or family members have chromosomal conditions.
  • Products of Conception: To determine the cause of miscarriage or pregnancy loss.

QF-PCR provides critical answers within days rather than weeks, allowing for timely medical decisions and reducing anxiety during this sensitive period.

Advantage

Our QF-PCR Advantage

At Suraksha Genomics, we offer state-of-the-art QF-PCR testing with significant advantages :

Key Features

  • Targeted Analysis : Specifically examines chromosomes 13, 18, 21, X, and Y—the most clinically significant aneuploidies.
  • Exceptional Speed : Results available in just 24-48 hours, compared to 10-14 days for conventional karyotyping.
  • High Sensitivity : Detection rate exceeding 99% for target aneuploidies.
  • Minimal Sample Requirement : Requires very small amounts of amniotic fluid or chorionic villus sample.
  • Complementary Testing : Often performed alongside microarray or karyotyping for comprehensive analysis.

Sample Types We Process

  • Amniotic Fluid : Collected during amniocentesis (typically 15-20 weeks).
  • Chorionic Villus Sampling (CVS) : For early pregnancy testing (10-13 weeks).
  • Products of Conception : For miscarriage tissue analysis.
  • Peripheral Blood : For postnatal confirmation of suspected aneuploidy

Testing Process

The QF-PCR Testing Process

Sample Collection

Sample Collection

A small amount of amniotic fluid (3-5 ml) or chorionic villus sample is obtained by your healthcare provider.

Sample Collection

Laboratory Processing

Sample preparation and PCR amplification in our facility.

Sample Collection

Genetic Marker Analysis

Examination of multiple genetic markers on each target chromosome.

Sample Collection

Expert Interpretation

Comprehensive analysis by our molecular genetics specialists.

Sample Collection

Rapid Reporting

Clear, clinically relevant results delivered to your healthcare provider within 24-48 hours.

Sample Collection

Genetic Counseling

Expert consultation to explain findings and implications.

Why Suraksha Genomics?

Why Choose Suraksha Genomics for QF-PCR Testing?

  • Industry-Leading Turnaround Time : Results available in 24-48 hours, among the fastest in the industry.
  • Comprehensive Quality Controls : Multiple internal and external quality assurance measures ensure reliable results.
  • Experienced Molecular Specialists : Analysis by experts with extensive experience in prenatal genetic diagnostics.
  • Integrated Genetic Services : Seamless coordination with other genetic tests when more information is needed.
  • Compassionate Patient Support : Dedicated genetic counselors to guide you through the testing process and results.
  • Preferred Provider : Trusted by leading maternal-fetal medicine specialists and obstetricians across Eastern India.

your Result

Understanding Your Results

Normal Result

Shows the expected two copies of chromosomes 13, 18, and 21 and appropriate sex chromosomes.

Trisomy

Indicates three copies of a specific chromosome (trisomy 13, 18 or 21).

Sex Chromosome Abnormalities

Detects conditions like Turner syndrome (single X), Klinefelter syndrome (XXY) and other variations.

Triploidy

Identifies presence of an extra complete set of chromosomes.

FAQs

Frequently Asked Questions

What is QF-PCR for Aneuploidy?

Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) is a rapid molecular genetic test used to quickly count the number of specific chromosomes. It's highly effective for detecting common aneuploidies.

What conditions does Suraksha Genomics QF-PCR screen for?

Our QF-PCR test screens for aneuploidies involving:

  • Chromosome 13 (Patau syndrome)
  • Chromosome 18 (Edwards syndrome)
  • Chromosome 21 (Down syndrome)
  • X and Y chromosomes (Sex Chromosome Aneuploidies like Turner syndrome, Klinefelter syndrome)
What samples are used for QF-PCR?

QF-PCR can be performed on Amniotic Fluid (AF), Chorionic Villus Samples (CVS), or blood samples.

When is QF-PCR recommended?

QF-PCR is often used when rapid detection of common aneuploidies is critical, such as in prenatal diagnosis following a high-risk screening result, or for newborns with suspected chromosomal disorders. It provides results much faster than Karyotyping.

Have Questions?

We understand the anxiety that can accompany prenatal testing. Our team of specialists is here to provide information, guidance, and support throughout your testing journey.

Contact our team today. Experience the peace of mind that comes from rapid, reliable answers from Eastern India's premier genetics laboratory.

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